Author

S. Ferguson

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Open access Sep 2026

Clinical factors associated with leptomeningeal disease in patients with melanoma brain metastasis

Abstract Background Leptomeningeal disease (LMD) is a severe manifestation of metastatic cancer with limited treatment options and a poor prognosis. Melanoma has one of the highest rates of leptomeningeal spread among solid tumors. Given the associated morbidity and mortality, identifying clinical factors linked to LMD...

M. Hasanov, C. A. Faraj, D. Milton et al. · Neuro-Oncology Advances · 0 citations

Sep 2026

Surgery and tile-based radiation therapy versus surgery and stereotactic radiation for newly diagnosed brain metastases (ROADS): a randomized, open-label, phase 3 trial.

PURPOSE Post-operative stereotactic radiation (SRT) is the standard-of-care for resected brain metastases. Implantation of cesium-131 collagen tiles (tile-based radiation therapy, TBRT) initiates focal radiation immediately after resection, potentially offering therapeutic and logistical advantages. ROADS: a randomized...

J. Weinberg, B. Imber, V. Dinapoli et al. · Journal of Clinical Oncology · 0 citations

Sep 2026

Explainable Machine Learning Model for Post-SRS Overall Survival Estimation in Renal Cell Carcinoma Brain Metastases Patients

Brain metastases (BM) from renal cell carcinoma (RCC) significantly affect survival, and disease-specific prognostic tools for patients undergoing stereotactic radiosurgery (SRS) remain limited. We aimed to identify prognostic factors and develop an interpretable machine learning (ML) model for individualized ris...

S. Ozgul, Melis Parabas, Peng Li et al. · Neuro-Oncology Practice · 0 citations