Open access
Sep 2026
Targeting epithelial IFN-I signaling restores barrier integrity in anti-TNF refractory Crohn’s disease
It is demonstrated that TNF signaling sustains epithelial IFN-I responses linked to immune regulation and antiviral pathways, establishing a mechanistic connection between chronic TNF signaling and epithelial barrier failure.
Safina Gadeock, Mikayla R. King, D. Polk et al.
· Journal of Crohn's & Colitis · 0 citations