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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Samir E. L. Andaloussi

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Open access Sep 2026

In Vitro Exploration of Antisense and Splice-Switching Oligonucleotide Multimers Using an Engineered Peptide Scaffold

Antisense oligonucleotides (ASOs) are potent therapeutics that enable precise RNA modulation. However, efficient delivery to tissues and cell types remains a major challenge. Multimerization, linking multiple ASOs to form large constructs, represents a promising strategy to explore delivery and pharmacokinetics modul...

Quentin Vicentini, Elena Grobecker, D. Daniele et al. · 0 citations
Aug 2026

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles

It is shown that an optimized single-guide RNA scaffold architecture improves RNP stability, and when combined with additional EV engineering leads to a three-hundred-fold increase in potency, enabling efficient base editing or knockout in primary cells, human brain organoids and in vivo, including the mouse brain.

Xiuming Liang, Houze Zhou, Z. Nizamudeen et al. · 0 citations

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