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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

S. Dehm

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Open access Sep 2026

Dynamics of circulating tumor cell subsets defined by PSMA and EpCAM predict survival in metastatic castration-resistant prostate cancer patients treated with 177Lu-PSMA-617

Background 177Lu-PSMA-617 radioligand treatment represents a major advancement in the management of metastatic castration-resistant prostate cancer (mCRPC), but key questions remain about tumor-cell dynamics and evolution in patients who have received this drug. Here, we used a circulating tumor cell (CTC) capture assa...

Madeline J. Lee, Lauren Yu, Nicholas A. Zorko et al. · 0 citations
Open access Aug 2026

Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis.

MYC-driven (MYC+) cancers are highly aggressive and often fatal. MYC dysregulation is a key event in these cancers, yet MYC overexpression alone is often insufficient to initiate or sustain tumorigenesis. Plasmocytoma variant translocation 1 (PVT1), a long noncoding RNA (lncRNA) adjacent to MYC on chromosome 8q24, is f...

Ashutosh Tiwari, Utkarsha Paithane, K. Tashiro et al. · 0 citations
Aug 2026

Longitudinal Phenotyping of Circulating Tumor Cells using a Scalable Deep Learning Framework.

This work developed and clinically validated the System for Enhanced Evaluation of Tumor Cells (SEE-TC), a deep learning approach for scalable, reproducible phenotyping of individual circulating cells that is the first fully automated AI approach to single-cell segmentation and CTC phenotyping.

M. Bootsma, M. Sharifi, J. Sperger et al. · 0 citations

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