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Author

S. Dawson

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Sep 2026

Diagnostic and therapeutic impact of genomic testing in neuroendocrine neoplasms.

Neuroendocrine neoplasms (NENs) are a diverse group of rare cancers with high heritability and limited treatment options for metastatic disease. Genomic testing guidelines for patients with NENs are limited to germline testing in high-risk individuals and tumour mutational burden (TMB) in a subset of patients. Here, we...

Emma Boehm, Aidan J. Flynn, Wing Fai Nip et al. · 0 citations
Jul 2026

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

It is shown that DNMT1 is enriched at unmethylated CpG islands of actively transcribed genes largely by its CXXC domain, and RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promoting the suppression of endogenous retroviral element-dependent viral mimicry.

Brian J. Liddicoat, Jesse J. Balic, W. Jia et al. · 1 citation

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