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Author

S. Comai

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Open access Aug 2026

Melatonin system integrity shapes gut-brain interaction in schizophrenia-derived microbiota transplant phenotype in mice.

AIMS This study investigates whether the melatonin (MLT) system modulates the behavioral, neurophysiological and neurochemical effects of fecal microbiota transplantation (FMT) from individuals with schizophrenia (SCZ), highlighting the role of the tryptophan (Trp) to MLT and kynurenine (Kyn) pathways. MATERIALS AND...

B. Barzon, A. Shkodra, M. D'Incalci et al. · 0 citations
Open access Sep 2026

668. Serotonin, melatonin, and kynurenines: bridging neurochemical pathways in schizophrenia and beyond

Investigating the interplay between Trp metabolism, inflammation, and gut microbiota in modulating cognitive and metabolic phenotypes in schizophrenia suggests that dysregulated Trp metabolism acts as a translational bridge connecting genetic background, metabolic status, and microbiota-derived signals to SCZ pathophys...

B. Barzon, A. Shkodra, S. Nasini et al. · 0 citations
Jun 2026

Mutations in the three synapsin genes lead to profound social deficits and cortical dysfunctions.

Results show that synapsin deletion is associated with a distinct profile of social and repetitive behavioral abnormalities, accompanied by a region-selective alteration in IL-mPFC firing activity, which indicates a marked deficit in sociability and social recognition in TKO mice.

Noemi Nicosia, Elena Monzani, Maria Regoni et al. · 0 citations

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