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Open access Sep 2026

Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.

Immune elimination of chronic infection or cancer requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process. Here, we report the ability of D-α-hydroxybutyrate (DAHB) to act as a signaling molecule that increases mitochondrial ATP pr...

Charles Ng, Tak-Shun Fung, Da-Yi Li et al. · 0 citations
Open access Aug 2026

Proton motive force as a driver of persister sensitization by adenosine.

Antibiotic tolerance and persistence contribute to the emergence of antimicrobial resistance, yet strategies to reverse these phenotypes remain limited. Our previous work revealed that the naturally occurring nucleoside adenosine can reverse antibiotic tolerance in diverse bacterial strains by modulating cellular energ...

Noah T. Thompson, David A. Kitzenberg, Alexander S. Dowdell et al. · 0 citations

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