Author

S. Cloonan

3 papers indexed here

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Open access Sep 2026

Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer

Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is unclear. Here, we show that elevated serum hepcidin is associated with reduced survival and decreased intratumoral CD8+ T...

J. Schoenfeld, Jahi J. Noel, Christopher S. McGinnis et al. · bioRxiv · 0 citations

Open access Oct 2026

Fatty acid-dependent cidality in Mycobacterium avium and Mycobacterium abscessus: intracellular acidification by itaconic acid.

Non-tuberculous mycobacterial (NTM) lung disease is now recognized as a chronic condition with considerable morbidity and mortality with incidence rising globally. This is concerning as these infections are often mis- or undiagnosed and currently available treatment regimens have lengthy (>1 year) treatment courses wit...

Hannah Lynch, R. Murray, D. Cox et al. · Microbiology · 0 citations

Review Open access Sep 2026

Fuelling repair: metabolic regulation of alveolar type 2 cell fate in lung regeneration and disease.

There is growing scientific interest in uncovering the mechanisms of lung regeneration, aiming to inform the development of innovative therapies for irreversible lung damage associated with chronic diseases. Cellular metabolism and its associated metabolites are increasingly recognised as active regulators of stem cell...

Sophia Wugk, S. Kenny, Filza Masood et al. · Disease Models & Mechanisms · 0 citations