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Author

S. Cheshier

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Sep 2026

Abstract PR007: Overcoming drug resistance in Sonic hedgehog-driven medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor in children, and the Group 2 (Sonic Hedgehog; SHH) subtype is driven by aberrant activation of the SHH signaling pathway. Several FDA-approved therapies target oncogenic SHH signaling by inhibiting SMOOTHENED (SMO), the primary membrane-associated regulato...

Rodney A. Stewart, Mattie Casey, Annabel Lee et al. · 0 citations

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