S. Caswell

611. MT1980: translating anti-inflammatory and metabolic mechanisms into new treatment opportunities for schizophrenia

Abstract Background Neuroinflammation contributes to the pathophysiology of schizophrenia in up to 50% of patients and is associated with the persistence of negative symptoms, a major unmet clinical need. Inflammatory activation of the kynurenine pathway disrupts dopaminergic and glutamatergic signalling, mechanisms ce...