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Author

Shi-Teng Cai

2 papers indexed here

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Open access Oct 2026

Region-specific cellular ecosystems govern divergent remodelling trajectories in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) exhibits marked regional heterogeneity despite shared sarcomere gene mutations. The molecular basis underlying preferential septal hypertrophy and relative apical preservation remains poorly understood. To define region-specific cellular programs and intercellular signalli...

Y. Tan, Z. Wang, Y. Song et al. · 0 citations
Open access Sep 2026

Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases.

Epigenetic regulation may underlie asymmetric allelic expression of many genes during development and disease pathogenesis. Allele-specific epigenetic modification could provide an efficient therapy for dominant genetic diseases due to heterozygous mutations. We developed an allele-specific epigenetic editing method ("...

Zheng-Min Wang, Cheng-Zhi Han, Yi-Ming Huang et al. · 1 citation

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