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Sep 2026

Abstract A118: Leveraging metabolic restriction in cooperation with SHP2 deficiency to inhibit PDAC

SHP2 (Ptpn11) is a tyrosine phosphatase well defined by its role in the MAPK pathway, including modulation of KRAS activity. KRAS is mutated in >90% of Pancreatic Ductal Adenocarcinoma (PDAC), which is the third leading cause of US cancer deaths. Mutant KRAS drives uncontrolled cell proliferation and cancer growt...

McKinnon Walsh, Austin E. Eades, Bailey A. Bye et al. · 0 citations
#protein folding Open access Oct 2026

Integrated pituitary adaptations to the low estrogen state

Estrogen’s broad trophic effects on anterior pituitary function are not fully understood. The compound 4-vinyl cyclohexene diepoxide (VCD) induces early ovarian failure and reduced E2 production, which may differentially affect anterior pituitary cells. We recently identified transcriptomic changes in pituitary gon...

Tiffany K. Miles, Angela K. Odle, Ashley K. Herdman et al. · 0 citations

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