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S. Bryant

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Open access Sep 2026

Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis

Endometriosis is a chronic inflammatory disorder affecting 5–10% of women of reproductive age and is associated with chronic pain and infertility. While research has mainly focused on local lesions, systemic immune dysfunction is increasingly implicated in disease pathogenesis. This study employs single-cell RNA sequen...

M. Rezk-Füreder, M. Kazemi, A. A. Gyunesh et al. · 0 citations
Open access Sep 2026

A combination of MD-derived pharmacophores and structure-based strategy identifies dual allosteric inhibitors of NS2B-NS3 proteases in Zika and West Nile viruses.

This integrated computer-aided drug design (CADD) strategy demonstrates the power of dynamic, structure-based pharmacophores to uncover novel allosteric inhibitors and accelerate antiviral drug repurposing.

A. Lupia, Salvatore Nieddu, Laura Demuru et al. · 0 citations

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