S. Brar

Integrating New Approach Methodologies and Artificial Intelligence to Advance Central Nervous System Toxicity Prediction: Lessons from Preclinical and Clinical Case Studies.

Central nervous system (CNS) toxicities remain a major cause of drug attrition and represent a persistent challenge in predicting neurological risk during drug development. Limitations in the predictive resolution and translational relevance of conventional nonclinical paradigms contribute to uncertainty in identifying...