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Open access Sep 2026

Leg muscle assessment by HR-pQCT and DXA: associations between imaging measures and muscle function in adults with obesity—a pilot study

Abstract DXA and HR-pQCT are used for bone assessment but also image adjacent soft tissue. This pilot study examined association between HR-pQCT-measured leg muscle cross-sectional area (CSA) and density vs DXA-derived lean mass, and explored associations with muscle strength, power, and physical performance in adults...

Søren Gam, Joshua R. Stapleton, Vivian Jing et al. · 0 citations
Open access Jul 2026

Impact of calibration approach on image quality and volumetric bone mineral density in low-dose chest computed tomography

Findings show that calibration strategy affects both image quality and vBMD agreement in low-dose chest CT, and asynchronous and tissue-based internal methods provided more consistent estimates than synchronous calibration, supporting their use for opportunistic osteoporosis assessment.

B. Matheson, Matthias Walle, S. Boyd · 0 citations
Open access Aug 2026

Establishing the precision of regional and voxel-wise bone mineral density measurements at the knee using dual-energy quantitative computed tomography.

Using DE-QCT, this study provided spatial maps of reproducibility for voxel-wise BMD measurements in the distal femur, proximal tibia, and patella and found SDRMS provides a more stable and interpretable precision metric than CVRMS and is recommended for voxel-based comparisons.

Nina Pavlovic, Julio Carballido-Gamio, Yousif Al-Khoury et al. · 0 citations
Open access Aug 2026

Type 2 Diabetes and Longitudinal Changes in Cortical and Trabecular Bone Density, Microarchitecture, and Strength: The Framingham Study.

The magnitude of peripheral bone loss over 8 years did not differ between individuals with type 2 diabetes and those with normoglycemia, suggesting that bone deterioration alone does not explain the higher fracture risk in older adults with type 2 diabetes.

A. Dufour, M. Bouxsein, Mu-Song Gao et al. · 0 citations

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