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Author

S. Bournazos

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Open access Oct 2026

Mechanistic basis for the selective recognition of the Fcγ receptor IIa by monoclonal antibody IV.3.

The monoclonal antibody IV.3 selectively binds the platelet Fcγ receptor IIa (FcγRIIa), potently blocking immune complex engagement without cross-reacting with the closely-related FcγRIIb. This specificity has made IV.3 invaluable for dissecting FcγRIIa-mediated activation in diverse conditions, including infection, au...

Jia-Ling Wang, Sabina Novack, Ji-Hong Li et al. · 0 citations
Open access Sep 2026

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

It is shown that plasma IgG reactivity to this region remains rare, even after repeated antigen exposure, and kinetic and avidity constraints governing neutralization at the HR2 stem helix and position hr2.016 as a resilient therapeutic candidate.

Virginia Crivelli, Concetta Guerra, M. Abernathy et al. · 0 citations

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