Open access
Sep 2026
BCL-2 inhibition at antiretroviral therapy initiation reduces the intact SIV reservoir in macaques.
The anti-apoptotic molecule BCL-2 favours the maintenance of the CD4+ T-cell reservoir during HIV infection. Whether inhibition of BCL-2 can lead to long-term reduction of the HIV reservoir is unclear. Here we initiated antiretroviral therapy (ART) in 24 simian immunodeficiency virus (SIV)-infected rhesus macaques at 1...
T. R. Wiche Salinas, J. Harper, C. Deleage et al.
· Nature Microbiology · 0 citations