In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Abstract We present a best‐practices protocol for targeted DNA methylation sequencing analysis that integrates both bisulfite‐ and enzymatic‐conversion approaches using Twist Bioscience technology. Building on established tools and vendor‐recommended workflows, this protocol provides a standardized, fully reproducible...
Vitória Rodrigues Guimarães Alves, Sheila T. Nagamatsu, V. Ota et al.· Current Protocols· 0 citations
This most comprehensive assessment of epigenetic and brain age models across development is provided, evaluating how these models associate with chronological age and with each other, and how these associations change across development.
Marlene Staginnus, V. Baltramonaityte, I. Schuurmans et al.· bioRxiv· 0 citations
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