Open access
Aug 2026
Sleep fragmentation and heightened inflammation: A latent profile subtype predicting nine-year major depressive disorder severity in the MIDUS study
A neuroimmune profile characterized by proinflammatory activity and insufficient, fragmented sleep functioned as a distal risk factor of MDD symptoms and a person-centered, multimodal risk stratification approach may enhance targeted prevention of long-term MDD.
Nur Hani Hani Zainal, S. Beaudreau
· Brain, Behavior, & Immunity... · 0 citations