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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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S. Bayle

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Oct 2026

Discovery and Optimization of Isoform Selective ULK1 Degraders to Enhance Antitumor Activity in KRAS-Mutant Cancer

Selective targeting of ULK1 represents a promising approach to overcome autophagy-mediated resistance in KRAS-driven cancers. However, achieving selectivity over the closely related ULK2 isoform with ATP-competitive inhibitors remains challenging due to the high sequence homology within their kinase domains. Here, we...

Sean Chin Chan, S. Bayle, Micheal Lamptey et al. · 0 citations

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