Background: Levodopa therapeutic response depends on factors that determine the optimization of drug absorption and distribution. In this perspective, gastrointestinal disorders in Parkinson's disease (PD), such as constipation and gastroparesis, act as an important barrier to effective treatment, increasing the degrad...
Nara Samara Silva Felipe dos Santos, Geane Vasconcellos de Vasconcelos, Gabriel Teles de Oliveira Piñeiro et al.· ANPAbstract_CBN26· 0 citations
Background: Current Parkinson’s disease therapies are often limited by adverse events from D2/D3 receptor activation. Tavapadon, a novel selective D1/D5 partial agonist, emerges as a promising alternative for effective motor control with an improved safety profile. Objective: To perform a systematic review, meta-analys...
João Victor Teixeira Costa, S. Baran, João Pedro Fernandes Gonçalves et al.· ANPAbstract_CBN26· 0 citations
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