S. Balachander

Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium.

OBJECTIVE Obsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to maintenance of obsessions and compulsions. This mega-analysis investigates neural activation during response inhibition and error processing using adult (OCD=563; co...

Regional and network-level resting state functional connectivity markers of pharmacological treatment resistance in obsessive-compulsive disorder

A transdiagnostic evaluation of adult temperamental profiles and their interactions with childhood adversities across major psychiatric disorder.

BACKGROUND Temperamental profiles and adverse childhood experiences (ACEs) have been reported in most major psychiatric disorders. However, the nature of this relationship is complex and under-studied. METHODS A total of 1162 individuals (N = 532 affected; N = 457 unaffected first-degree relatives (FDRs) and N = 173...

Lifespan brain structural variation reveals shared organization across mental health conditions

Large-scale evidence is provided that structural deviations across NDPCs are systematically constrained by the brain's intrinsic architecture, providing a framework for reconciling individual variability with transdiagnostic similarities and motivates an integrative, systems-level understanding of mental health.