Aug 2026
Mena EVH1 Interacts with PTP1B Via a Distributed Interface Without Regulating Enzymatic Activity.
The solution NMR structure of the unliganded Mena EVH1 domain is reported, which contains a conserved aromatic triad that forms the canonical polyproline-binding cleft that supports a model in which Mena functions as a scaffold to spatially organize PTP1B within EGFR signaling complexes.
Lanette LaComb, Sean M. Cahill, J. Bonanno et al.
· Biochemistry · 0 citations