Comparing HbS Haplotypes Identified with Different Sets of Single Nucleotide Polymorphisms: An Analysis in a Sample of HbAS and HbSS Individuals from São Tomé e Príncipe
ABSTRACT:Sickle cell anemia occurs in individuals who are homozygous for the sickle hemoglobin (HbS) allele. The haplotypes of the HbS alleles can be traditionally ascertained through the analysis of five to eight informative restriction fragment length polymorphisms within the HBB gene cluster, defining the five major...