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Author

Saleh Alkhedhairi

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Review Aug 2026

Small-molecule disruption of the TRAF6-Ubc13 protein-protein interaction: targeting noncanonical ubiquitin signaling in inflammation and cancer.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a central E3 ubiquitin ligase that links immune-receptor activation to nondegradative K63-linked ubiquitin signaling. Through its functional cooperation with the E2 enzyme Ubc13/UBE2N and Uev1A, TRAF6 promotes the formation of polyubiquitin scaffolds that ac...

S. Alkhedhairi · 0 citations

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