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Author

Ryoko Okamoto

2 papers indexed here

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Open access Sep 2026

SALL1 and neural microenvironmental context specify identity of stem cell derived human microglia-like cells

Microglia, the immune cells of the brain parenchyma, play a pivotal role in neurodevelopment and neuroprotection. Human stem cell-derived microglia-like cells (MGL) offer a valuable, human-relevant system to study microglia in vitro. However, their cell states and intercellular interactions within complex 3-dimensional...

Marina T. Nikolova, Kiara Freitag, Ryoko Okamoto et al. · 0 citations
Open access Jul 2026

Live single-molecule imaging reveals global shifts in mRNA mobility during human stem cell differentiation

Spatiotemporal regulation of mRNA localisation is fundamental to cell identity specification and function, yet tracking transcript dynamics in living differentiating cells remains technically challenging. Here, we establish a robust pipeline for MS2 tagging of endogenous transcripts in human induced pluripotent stem ce...

Aileen-Diane Bamford, Gilles Gut, Tim-Oliver Buchholz et al. · 0 citations

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