Ryan J. Rutledge

From Daffodils to Drug Leads: Amaryllidaceae Alkaloids Target Protein Translation in Chronic Lymphocytic Leukemia to Induce Selective Apoptosis

Targeting protein translation is a promising strategy in oncology, especially for malignancies dependent on short-lived survival factors. The clinical translation inhibitor homoharringtonine (HHT) was recently discontinued in the U.S. due to poor solubility and cardiotoxicity, creating an urgent need for new leads. W...