Aug 2026
Tuning HDAC Inhibition, Cell Uptake, and Antiproliferative Activity of Vorinostat-Derived Half-Sandwich Complexes with Phosphine Co-Ligands.
To alter the interactions between HDACs and half-sandwich organometallic HDACis, amphiphilic 1,3,5-triaza-7-phosphaadamantane (PTA) or lipophilic triphenylphosphine (PPh3) as coligands were introduced or Rh(III) derivatives exhibited promising antiproliferative and HDAC inhibitory activity compared to their chlorido pr...
Chen Chen, Barbora Havlinova, M. Vošahlíková et al.
· Inorganic Chemistry · 0 citations