Zuogui Wan preserves Leydig cell steroidogenesis via G6PD/NADPH/GSH-dependent ferroptosis inhibition in D-galactose-induced hypogonadism.
ETHNOPHARMACOLOGICAL RELEVANCE Zuogui Wan (ZGW), a classical formula for aging-related disorders, may delay reproductive decline, but its effects on late-onset hypogonadism (LOH) remain unclear. AIM OF THE STUDY To investigate the effects and underlying mechanisms of ZGW in LOH using rat and cellular models by integr...