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Author

Ruo-Lan Chen

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2 papers indexed here

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Oct 2026

Mcu upregulation triggers mitochondrial oxidative stress and cardiomyocyte injury after myocardial infarction yet is suppressed by Fto and Ythdf2 in an m6A-dependent manner.

It is demonstrated that elevated Mcu is positively associated with MI risk; excess Mcu triggers mitochondrial calcium overload, ROS buildup, mitochondrial membrane potential loss and respiratory chain damage to facilitate cardiomyocyte damage, whereas Mcu knockdown alleviate these pathological alterations.

Ruo-Lan Chen, Xue-Zhe Wang, Lu-Ning Qin et al. · 0 citations
Open access Sep 2026

BMSC-derived EVs alleviate doxorubicin-induced cardiotoxicity via miR-210-3p involving the ACVR1B-SMAD3-PGC-1α signaling axis

Doxorubicin-induced cardiotoxicity (DIC) limits the clinical use of doxorubicin, yet no specific therapeutic interventions are available. Although the cardioprotective role of miR-210 and the therapeutic potential of stem cell-derived extracellular vesicles have been reported, the specific downstream effectors and path...

Ruo-Lan Chen, Lu-Ning Qin, Ning Zhang et al. · 0 citations

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