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Ruo-Bing Ren

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Open access Sep 2026

Lineage-specific enzyme optimization underlies divergent evolution of trans-Cinnamaldehyde and Eugenol biosynthesis in Cinnamomum cassia and Cinnamomum verum.

Closely related plant species often exhibit striking diversity in their specialized metabolism, yet the genomic and evolutionary mechanisms driving this divergence are often elusive. The globally important cinnamon species Cinnamomum cassia and C. verum represent a classic example, producing leaf essential oils dominat...

Peng Ye, Lei-Ye Yu, Yan-Qun Li et al. · 0 citations
Jul 2026

Designing Fidelity of CRISPR-Cas Endonucleases by Kinetic Insights

A PLM-assisted physics-driven approach is presented that utilizes atomistic molecular dynamics simulations and automated path searching to efficiently obtain the complete kinetic insights, including the transition state structures, for the conformational changes of Cas before DNA cleavage.

Huihui Liu, Zhenyu Zhou, Luowei Yuan et al. · 0 citations

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