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RNA function arises from the coupling of nucleotide sequence and three-dimensional structure, motivating their joint design. Coordinating global folding with nucleotide-level detail remains challenging under limited structural supervision. We introduce La-Ribo, a generative framework for RNA sequence-structure co-desig...
TRACE is proposed, a Tractable Routing Autoencoder for Clinical ECG, whose 32-dimensional clinical latent space is specified in advance from domain knowledge rather than discovered by optimization, and reconstructs the ECG through a decoder that permits latent perturbation.
LiteMedCoT-VL is introduced, a pipeline that transfers chain-of-thought reasoning from a 235B teacher model to 2B student models through LoRA-based fine-tuning on explanation-enriched training data, and indicates that a 2B model with reasoning distillation can match or exceed models with twice the parameters.
BEAT-Net is presented, a supervised biomimetic framework that integrates QRS-centered biological tokenization with a hierarchical architecture mirroring the cardiologist's workflow, demonstrating that explicit physiological structure provides a more efficient and interpretable alternative to massive pre-training for cl...
AAMFM, an Antigen-specific Antibody Multimodal Foundation Model that learns unified representations of antibody sequences and structures conditioned on antigen context, achieves state-of-the-art performance in functional antibody design, revealing its potential for antigen-specific antibody engineering.
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