Author

Runkai Zhao

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Sep 2026

Targeting the PRMT5-CBX8 axis overcomes dual barriers of CD8⁺ T cell exclusion and tumor stemness for sensitizing TNBC to anti-PD-1 therapy

A novel epigenetic pathway orchestrated by PRMT5 that converges on the functional modulation of CBX8 to synchronously governs CD8⁺ T cell exclusion and tumor stemness is unveiled, nominating PRMT5 inhibition as a compelling therapeutic strategy for combination immunotherapy in TNBC.

Cong-Cong Chen, Yu-Heng Zhang, Chang Liu et al. · Oncogene · 0 citations

Jul 2026

SciDataSailor: Deep Scientific Data Exploring

This work presents SciDataSailor, a framework for synthesizing tool-interactive trajectories by balancing broad exploration with targeted exploitation and presents SciDataSailor, a framework for synthesizing tool-interactive trajectories as Monte Carlo Tree Search (MCTS) with four task-specific mechanisms.

J. Rao, Yicheng Qiu, Chi Zhang et al. · arXiv.org · 1 citation