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Author

Run Shi

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Open access Oct 2026

Integrative single-cell and computational pathology analyses reveal a C11orf24-associated stem-like epithelial population linked to tumor microenvironment remodeling and immune evasion in bladder cancer.

BACKGROUND Cancer stem-like cells drive tumor progression and therapeutic resistance, yet the epithelial stemness hierarchy in bladder cancer (BLCA) remains poorly defined. We aimed to characterize stemness-associated epithelial populations and their clinical significance. METHODS We analyzed single-cell RNA sequenci...

Ying-Jian Wang, Song-Xin Zhang, Xi Luo et al. · 0 citations
Open access Aug 2026

Integrative multi-omics reveals the POSTN+ CAF–APOE+ macrophage axis drives immunosuppression and progression in prostate cancer

An integrated single-cell atlas defines a critical POSTN+ CAF–APOE+ macrophage unit that is associated with a fibrotic and immunosuppressive TME in advanced prostate cancer, and suggested conserved enrichment and adverse prognostic impact of this stromal-immune axis across diverse tumor types, though tissue-specific co...

Yangzhou Liu, Ao-Chu Liu, Xing-Lai Dai et al. · 0 citations

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