Sep 2026
POLE2 of tumor cells promotes OPN secretion based on PCLAF to drive M2 macrophage polarization in clear cell renal cell carcinoma.
A comprehensive NFATc2/POLE2/PCLAF signaling axis that promotes ccRCC progression via OPN-mediated M2 macrophage polarization, providing a solid rationale and potential therapeutic targets for developing novel immunocombination therapies is unveiled.
An-Rui Li, Jing-Wen Xu, Zhi-Hang Wu et al.
· Cancer Gene Therapy · 0 citations