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Author

Run-Qiu Jiang

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Sep 2026

Chronic Ileitis Ameliorates Hyperglycemia via a 3-HB/NKX6.1 Axis in Mice.

A novel gut-islet axis where microbiota-derived 3-HB preserves β-cell functional identity via HCAR2 dependent regulation of NKX6.1 is identified, offering a potential therapeutic strategy for type 2 diabetes.

Yi Fang, Chang Zheng, Ping Jiang et al. · 0 citations
Open access Sep 2026

Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer

This study identifies a novel ‘PD-L1–ER stress–pyruvate–macrophage senescence’ axis as a key mechanism underlying primary resistance to ICB and proposes that targeting the PDK4/GLS-dependent pyruvate surge offers a promising therapeutic strategy to sensitize tumors to anti-PD-1 immunotherapy.

Wen-Xin Lian, Hui Yang, Yu-Qi Zhang et al. · 0 citations

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