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Run-Kai Cai

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Open access Aug 2026

RMI2 depletion recovers cGAS-STING signaling to enhance immunotherapy in colorectal cancer

Microsatellite-stable (MSS) colorectal cancers (CRCs) are largely refractory to immune checkpoint inhibitors (ICIs) due to immunologically “cold” tumor microenvironments (TMEs) characterized by limited T-cell infiltration. While RecQ-mediated genome instability 2 (RMI2) is known for regulating DNA repair, its role in...

Run-Kai Cai, E. Huang, Yina Liu et al. · 0 citations

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