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Author

Ruiyao Wang

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Open access Oct 2026

PLA2G4A-driven arachidonic acid metabolic reprogramming promotes NSCLC progression via the HSF1 signaling axis

Aberrant arachidonic acid (AA) metabolism is a hallmark of cancer, and cytosolic phospholipase A2 (PLA2G4A) is the rate-limiting enzyme that initiates this cascade. However, the cell-intrinsic role of PLA2G4A and its downstream signaling mechanisms in non-small cell lung cancer (NSCLC) remain poorly understood. Her...

Wei-Fang Wang, Ze Wang, Kun-Fang Li et al. · 0 citations
Open access Aug 2026

Network pharmacology-guided identification of Rabdosia rubescent as a suppressor of laryngeal cancer via MMP9-mediated extracellular matrix remodeling: integrated in silico and experimental validation

By effectively targeting the MMP9 pathway, Cirsiliol suppresses tumor invasiveness and migration, highlighting its potential as a promising lead compound for the treatment of laryngeal cancer.

Xue-Feng Wang, Guan-Ying Ren, Yong-Gang Zhang et al. · 0 citations

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