Open access
Aug 2026
Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair
ABSTRACT It is well established that mitochondrial DNA (mtDNA) synthesis governs macrophage function, yet its role in tissue repair and inflammation remains poorly understood. Using a mouse skin injury model combined with spatial transcriptomics and functional assays, we identify radical s‐adenosyl methionine domain co...
Hao-Miao Yuan, Shu-Kui Du, Chunfei Li et al.
· Advancement of science · 0 citations