Rui-Shi Wang

Predictive β-Sheet Protein Stabilization via Computationally Guided Metal Coordination with Simulations and AlphaFold3.

Proteins that withstand mechanical forces in nature possess evolved architectures that resist forced unfolding, yet mimicking this robustness in engineered proteins remains challenging. Although metal coordination bonds can act as powerful molecular clamps, their incorporation has been largely empirical, with no ration...