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Sep 2026
Accurate prediction of mutation-induced protein stability responses, including changes in folding free energy and melting temperature, is critical for protein engineering. Existing models represent these related but non-equivalent measurements separately and often focus on single mutations. Here we present OmegaTherm,...
Wen-Kang Wang, Yi-Hang Zhou, Wen-Tao Yu et al.
· bioRxiv · 0 citations
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Aug 2026
This work proposes scCLC, a topology-aware contrastive learning framework for clustering single-cell multi-omics data and introduces a dedicated multi-view data augmentation strategy to address modality-specific characteristics.
Zhenlan Liang, Rui-Qing Zheng, Huayu Tao et al.
· IEEE transactions on computa... · 0 citations
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Open access
Jul 2026
Across distinct experimental datasets, SRLST consistently outperforms existing methods in delineating cortical organization, identifying small discontinuous tissue compartments, and capturing complex intratumor heterogeneity.
Wei Lan, Xiao Deng, Tongsheng Ling et al.
· Bioinform. · 0 citations
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