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Author

Rui Liu

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2 papers indexed here

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Open access Sep 2026

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

A novel mechanistic insight is introduced into the pathogenesis of myeloma and bone deterioration and disruption of the ENO1–PTTG1 interaction is identified as a potential dual-targeting therapeutic strategy, demonstrating significant efficacy in curbing myeloma progression and osteolytic lesions.

Rui Liu, Ya-Zhu Huang, Z. Fang et al. · 0 citations
Open access Aug 2026

SEI1 complex silences p53 to drive myeloma progression

The findings elucidate the SEI1/HDAC1/FOXC1/p53 axis as a critical driver of myeloma progression and identify tiludronate disodium as a potential therapeutic agent.

Rui Chen, Rui Liu, Z. Fang et al. · 0 citations

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