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Review Open access Sep 2026

Oncolytic reovirus: tumor-microenvironment remodeling, engineering constraints, and translational strategies

Oncolytic reovirus (ReoV) has emerged as a promising cancer immunotherapy platform because of its natural tumor tropism and immunostimulatory properties. Reovirus enters susceptible cells through receptors including junctional adhesion molecule-A and exploits oncogenic signaling and impaired antiviral responses to pref...

Rui Li, Xia-Fei Liu, Xi-Liang Cong et al. · 0 citations

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