Open access
Oct 2026
Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo
Zachary Wu, Josh Abramson, Thomas Frerix et al.
· bioRxiv · 0 citations
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Open access
Oct 2026
Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry
It is demonstrated de novo enzyme design can enable challenging, high-energy-barrier enzyme chemistry with programmable regio- and enantioselectivity, high catalytic efficiency, excellent enzyme stability, and scaffold diversity.
Zi-Qi Li, Rui-Jie K. Zhang, Pei-Pei Xie et al.
· bioRxiv · 0 citations