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Review Aug 2026

Senescent repair memory in chronic disease: failed resolution as a driver of persistent organ dysfunction.

Chronic diseases can continue to progress after the initiating insult has subsided, indicating that injured tissues may retain a persistent imprint of failed repair. Here, senescent repair memory refers to a tissue state in which transient repair-associated senescence fails to resolve and is maintained by persistent se...

Hong-Tu Hu, Rui Ji, Ji-Jia Hu · 0 citations
Review Open access Aug 2026

Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy

Summary Acute kidney injury (AKI) is a heterogeneous syndrome for which creatinine and urine output incompletely represent underlying biology and temporal evolution. We organise AKI pathophysiology into four interconnected dimensions: initiation and effector injury; cell fate and immune microenvironment; repair and out...

Hong-Tu Hu, Zi-Kang Liu, Rui Ji et al. · 1 citation

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