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Open access Oct 2026

PWK genetic background reprograms heterochromatin and malignant epithelial states in Neu-driven mammary tumors

Genetic background can alter the latency and behavior of cancers initiated by the same oncogenic driver, but how inherited variation reshapes the regulatory landscape that permits tumor development remains poorly understood. The PWK genetic background accelerates mammary tumor onset in the NeuT model. We compared PWK N...

Rui Geng, Ryann R. Ray, J. Jacob et al. · 0 citations

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