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Oct 2026

A lymph node-targeted nanoplatform reprograms metabolic and immune microenvironments via dual ACSL3/4 inhibition in lymphatic metastatic tumors.

Lymph node metastasis in hepatocellular carcinoma depends heavily on lipid metabolic reprogramming, wherein the acyl-CoA synthetase long-chain family members ACSL3 and ACSL4 act as central survival hubs. However, single-target interventions often fail to curb metastasis due to the inherent metabolic plasticity and flex...

Bai-Xue Fu, Rui Gao, Zhi-Zheng Xie et al. · 0 citations
Open access Aug 2026

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming

Myocardial infarction (MI) is characterized by severe oxidative stress, excessive inflammation, and profound mitochondrial dysfunction. Although mitochondrial transplantation offers therapeutic promise for MI, its clinical translation is severely hampered by the extreme fragility of donor mitochondria with rapid loss o...

Hang Li, Yu-Shan Zhang, Yi-Fan Jian et al. · 0 citations

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