Mechanistic Study on HSP90B1 Regulation of ClC-7 Ubiquitination to Restore Lysosomal Function in the Protection Proffered by DGMI Against Fluoride-Induced Cognitive Dysfunction.
BACKGROUND Fluorosis can induce cognitive dysfunction. The cognitive impairment caused by fluorosis is closely related to endoplasmic reticulum stress (ERS) and abnormal lysosomal acidification. However, the specific molecular mechanism is not known, and effective intervention strategies are lacking. Diterpene ginkgoli...