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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Rufaida Al Zoubi

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Open access Sep 2026

Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit

Introduction Pim-1 is a serine/threonine kinase of the pan-Pim family (Pim-1, −2, and −3), whose overexpression is associated with various cancers. Its distinctive hinge-region architecture provides opportunities for selective inhibitor development, with several inhibitors reported as clinical candidates. Understanding...

Rufaida Al Zoubi, Omar Hadieh, Soraya Alnabulsi et al. · 0 citations
Open access Sep 2026

Discovery of novel acridine based inhibitors of Bruton’s tyrosine kinase (BTK) via pharmacophore modeling and machine learning-driven virtual screening followed by molecular dynamic studies

A key outcome of this study is the identification of a chemically distinct and novel, acridine-based antiproliferative hit candidates with measurable BTK inhibitory activity.

Rand O. Shahin, Sawsan Jaafreh, Iman A. Mansi et al. · 0 citations

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