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Rúbens P. Dos S Alves

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Open access Jul 2026

T cell-associated immunity induced by heterologous recombinant BCG and purified protein vaccination confers cross-variant protection against SARS-CoV-2

ABSTRACT Previously, we have developed a recombinant BCG-based vaccine (rBCG) expressing a chimeric protein with spike and nucleocapsid epitopes (rChimera) to combine BCG’s innate immune training capacity with SARS-CoV-2-specific adaptive immune responses. The heterologous prime-boost rBCG/rChimera+Alum regimen induced...

F. Mambelli, A. Gimenez, A. C. O. D. de Araujo et al. · 0 citations

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